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Updated: May 13, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Optimizing Therapeutic Drug Monitoring of Anti-infectives: Patient and Clinical Setting Considerations
Bernice A Agana1, William Clarke1
1Department of Pathology, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD 21287, USA.
Abstract:
Therapeutic drug monitoring (TDM) plays an essential role in personalized medicine, especially for anti-infective agents, due to the high global burden of infection-related morbidity and mortality. Achieving optimal therapy for antibacterial, antifungal, antiviral, and antimycobacterial agents can be challenging due to significant variability in pharmacokinetics/pharmacodynamics among different patients. This review explores the implementation of TDM and patient-related challenges using different anti-infective agents as examples across different clinical settings. TDM enables the implementation of a precision medicine approach, tailoring drug dosing to individual patient characteristics, disease states, and treatment variables.
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