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Updated: May 14, 2025

Author Spotlight: Developing a Rat Model for Pouchitis Research and Treatment
Published on: May 31, 2024
Optimal Approaches to Treating and Preventing Acute and Chronic Pouchitis by Altering Microbial Profiles
Govind Kallumkal1, Edward L Barnes2
1Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
None:
Pouchitis is the most common complication after restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. The authors review the role of the microbiota in both the pathogenesis of pouchitis, primarily via dysbiosis, as well as the resultant treatment strategies focused on correcting dysbiosis among patients with pouchitis. These include the role of antibiotics, probiotics, and potentially metabolomics in both treatment and risk stratification.
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