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Related Experiment Video

Updated: May 14, 2025

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High Intensity Focused Ultrasound - Longitudinal Data on Efficacy and Safety.

Betsy Thomas1, Gabriele Bellini2,3, Wen-Yu Lee4

  • 1Department of Neurology, NYU Langone Health, New York, USA.

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Summary

High intensity focused ultrasound (HiFU) is an effective treatment for essential tremor and Parkinson's disease tremor. Patients should discuss potential temporary adverse events like gait instability and tremor recurrence risks with their doctors.

Keywords:
Essential TremorFocused UltrasoundHiFUHigh IntensityParkinson’s Disease

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Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Devices

Background:

  • High intensity focused ultrasound (HiFU) is an emerging incisionless treatment for essential tremor and Parkinson's disease tremor.
  • Understanding HiFU's indications, benefits, risks, and limitations is crucial for patient selection.
  • Comparison with deep brain stimulation (DBS) aids in guiding treatment recommendations.

Purpose of the Study:

  • To review the current literature on the efficacy and safety of HiFU for tremor disorders.
  • To analyze patient data from a center for HiFU consultations, including specific patient subgroups.
  • To discuss emerging data and future directions for HiFU therapy.

Main Methods:

  • Systematic literature review of HiFU efficacy and safety studies.
  • Retrospective analysis of patient consultation data at a specialized center.
  • Inclusion of data on low skull density ratios and patient travel distance.

Main Results:

  • HiFU demonstrates effectiveness and good tolerability for tremor management.
  • Adverse events, such as gait instability, are generally temporary.
  • Consideration of patient-specific factors, recurrence risk, and practicalities is vital for candidate selection.

Conclusions:

  • HiFU is a viable option for tremor treatment, with temporary side effects.
  • Careful patient selection is paramount, considering individual circumstances and preferences.
  • Further research into bilateral HiFU, low skull density patients, and new targets is warranted.