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Nano-Spray-Drying of Cyclodextrin/Ibuprofen Complexes with Aerosolization-Enhancing Additives for Pulmonary Drug
Anett Motzwickler-Németh1, Endre Körmendi1, Árpád Farkas2
1Institute of Pharmaceutical Technology and Regulatory Affairs, Faculty of Pharmacy, University of Szeged, 6720 Szeged, Hungary.
International Journal of Molecular Sciences
|May 14, 2025
Summary
Cyclodextrins enhance ibuprofen solubility for lung delivery, improving cystic fibrosis treatment. Nano-spray drying created effective drug-carrier complexes with optimal aerodynamic properties for enhanced drug release.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Materials Science
Background:
- Poorly water-soluble drugs require enhanced delivery systems.
- Pulmonary drug delivery offers reduced dosage and side effects, beneficial for conditions like cystic fibrosis.
- Cyclodextrins (CDs) are effective carriers for improving drug solubility.
Purpose of the Study:
- To prepare and characterize cyclodextrin/ibuprofen (CD/IBU) complexes using nano-spray drying.
- To evaluate the aerodynamic properties and in vitro performance of these complexes for pulmonary delivery.
- To compare the efficacy of sulfobutylether-β-cyclodextrin (SBECD) and (2-Hydroxy-3-N,N,N-trimethylamino)propyl-beta-cyclodextrin chloride (QABCD) as carriers.
Main Methods:
- Nano-spray drying technique for complex preparation.
- Characterization using particle size analysis, SEM, XRPD, DSC, and FT-IR.
- In vitro evaluation via Andersen Cascade Impactor, dissolution, and diffusion tests, complemented by in silico simulations.
Main Results:
- Optimized formulations achieved approximately 50% fine particle fraction, indicating good aerosolization potential.
- Rapid in vitro drug release was observed for all formulations.
- QABCD-based formulations showed reduced membrane diffusion compared to SBECD due to electrostatic interactions.
Conclusions:
- Nano-spray drying is a viable method for preparing CD/IBU complexes for pulmonary delivery.
- Formulations exhibited favorable aerodynamic properties and rapid drug release.
- The choice of cyclodextrin (SBECD vs. QABCD) influences drug diffusion due to interactions, impacting overall delivery efficacy.
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