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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...

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Updated: May 16, 2025

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

CXCR4-Targeted Imaging in Takayasu Arteritis Using 68 Ga-Pentixafor PET/CT.

Thorsten Derlin¹, Torsten Witte²

¹Departments of Nuclear Medicine.

Clinical Nuclear Medicine

|May 14, 2025

Summary

This summary is machine-generated.

This study shows that 68Ga-Pentixafor PET/CT can detect active inflammation in Takayasu arteritis and identify cancer in patients at high risk. This imaging technique aids in diagnosing both inflammatory and neoplastic diseases.

Keywords:

CXCR4 PET/CT Pentixafor Takayasu arteritis chemokine receptor large vessel vasculitis

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Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography FDG-PET/CT

Published on: May 2, 2012

Area of Science:

Nuclear medicine
Oncology
Rheumatology

Background:

Takayasu arteritis is a large vessel vasculitis with potential for serious complications.
Patients with Takayasu arteritis have an increased risk of developing malignancies.
Accurate assessment of disease activity and exclusion of other inflammatory conditions are crucial for patient management.

Purpose of the Study:

To evaluate the utility of chemokine receptor CXCR4-targeted 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) in a patient with Takayasu arteritis.
To assess disease activity in Takayasu arteritis and exclude concurrent inflammatory diseases.
To identify potential neoplastic disease in a patient with an increased risk of malignancy.

Main Methods:

Whole-body 68Ga-Pentixafor PET/CT was performed on a 64-year-old woman diagnosed with Takayasu arteritis.
18F-fluorodeoxyglucose (FDG) PET/CT was used for confirmation of active disease.
Findings from PET/CT were correlated with clinical diagnosis.

Main Results:

68Ga-Pentixafor PET/CT revealed CXCR4-positive inflammatory cell infiltrates in the aortic wall, indicating active Takayasu arteritis.
Active disease was confirmed by 18F-FDG PET/CT.
68Ga-Pentixafor PET/CT also identified a CXCR4-positive pelvic bone lesion, leading to the diagnosis of diffuse large B-cell lymphoma.

Conclusions:

CXCR4-targeted 68Ga-Pentixafor PET/CT is a valuable tool for detecting active inflammation in Takayasu arteritis.
This imaging modality can identify neoplastic disease in patients with Takayasu arteritis, who are at higher risk for malignancy.
68Ga-Pentixafor PET/CT offers a dual capability in assessing both inflammatory and neoplastic processes in this patient population.