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Prognostic Effect of pan-Immune-Inflammation Value Indices in Patients with Acute Coronary Syndrome Undergoing

Yan Liu1, Xinchen Wang1, Ge Song1

  • 1Department of Cardiology, The Affiliated Hospital of Chengde Medical University, Chengde, China.

Clinical and Applied Thrombosis/Hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
|May 14, 2025
PubMed

Insights

Higher pan-immune-inflammation values (PIV), PIV/HDL-C, and PIV*LDL-C predict major adverse cardiovascular events (MACEs) in acute coronary syndrome (ACS) patients after percutaneous coronary intervention (PCI). These markers may serve as novel biomarkers for predicting MACEs in this population.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Acute coronary syndrome (ACS) poses significant cardiovascular risk.
  • Percutaneous coronary intervention (PCI) is a common treatment for ACS.
  • Prognostic markers are crucial for managing ACS patients undergoing PCI.

Purpose of the Study:

  • To investigate the association of pan-immune-inflammation value (PIV) and its ratios (PIV/HDL-C, PIV*LDL-C) with prognosis in ACS patients undergoing PCI.
  • To identify novel biomarkers for predicting major adverse cardiovascular events (MACEs) in this patient group.

Main Methods:

  • A cohort of 1360 ACS patients undergoing PCI was analyzed.
  • Patients were categorized into MACEs and non-MACEs groups.
  • PIV, PIV/HDL-C, and PIV*LDL-C values were measured and correlated with MACEs outcomes.

Main Results:

  • Elevated PIV (≥355.79), PIV/HDL-C (≥282.86), and PIV*LDL-C (≥1431.58) were identified as independent predictors of MACEs.
  • Multivariable Cox regression analysis confirmed these associations (all P < .05).
  • Patients with higher index values exhibited significantly lower cumulative survival rates (log-rank tests, P < .05).

Conclusions:

  • Higher PIV, PIV/HDL-C, and PIV*LDL-C are independent prognostic factors for ACS patients undergoing PCI.
  • These inflammatory indices may serve as novel biomarkers for predicting MACEs.
  • The findings highlight the role of systemic inflammation in ACS prognosis post-PCI.

Keywords:
HDL-CLDL-Cbiomarkermajor adverse cardiovascular eventsprognosissurvival

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