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Association of the Geriatric Nutritional Risk Index With Prognosis in Patients With Acute Coronary Syndrome

Yuewen Qi1,2, Xinchen Wang3, Yan Liu3

  • 1Hebei Key Laboratory of Panvascular Diseases, Chengde, China.

Immunity, Inflammation and Disease
|January 15, 2026
PubMed

Insights

The Geriatric Nutritional Risk Index (GNRI) can predict major adverse cardiovascular events (MACEs) in acute coronary syndrome (ACS) patients after percutaneous coronary intervention (PCI). Lower GNRI indicates a higher risk of MACEs, including cardiac death and rehospitalization.

Area of Science:

  • Cardiology
  • Nutritional Science
  • Geriatrics

Background:

  • The Geriatric Nutritional Risk Index (GNRI) is a known predictor for certain diseases.
  • Its predictive value for major adverse cardiovascular events (MACEs) in patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI) is not well-established.

Purpose of the Study:

  • To investigate the association between the GNRI and the risk of MACEs in ACS patients who underwent PCI.

Main Methods:

  • A prospective cohort study enrolled 1515 ACS patients undergoing PCI.
  • Follow-up duration was a median of 1000 days.
  • Primary endpoints included MACEs: all-cause mortality, heart failure rehospitalization, revascularization, recurrent acute myocardial infarction (AMI), and restenosis/stent thrombosis.

Main Results:

  • A GNRI cutoff of 110.78 was identified via ROC analysis.
  • Lower GNRI levels were independently associated with increased MACE risk, higher rehospitalization rates, and cardiovascular death.
  • Kaplan-Meier curves and Cox regression confirmed these associations, even after adjustments.

Conclusions:

  • GNRI serves as a valuable indicator of nutritional status and predicts MACEs in ACS patients undergoing PCI.
  • It is particularly useful for identifying patients at high risk for cardiac death and rehospitalization, suggesting a poor prognosis.
Abstract

Keywords:
acute coronary syndromegeriatric nutritional risk indexmajor adverse cardiovascular eventspercutaneous coronary intervention

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