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Updated: May 16, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
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Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate

Published on: June 21, 2017

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Direct Amination of Anilines Utilizing Dearomatized Phenolate Species

Shaofeng Wu1, Haitao Li1, Shicheng Dong2

  • 1State Key Laboratory of Chemistry and Utilization of Carbon-Based Energy Resources, Key Laboratory of Oil and Gas Fine Chemicals, Ministry of Education & Xinjiang Uygur Autonomous Region, Urumqi Key Laboratory of Green Catalysis and Synthesis Technology, College of Chemistry, Xinjiang University, Urumqi 830017, China.

Organic Letters
|May 15, 2025
PubMed
Summary

Directly aminating anilines is now possible using hypervalent iodine to create transient intermediates. This method efficiently synthesizes bioactive p-alkylaminophenols for drug discovery and complex amine construction.

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