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Updated: Jun 13, 2025

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
Published on: December 28, 2017
Phylogeny-guided discovery of new antifungals
Nicolas Papon1, Vincent Courdavault2, Vishnu Chaturvedi3
1University of Angers, University of Brest, IRF, SFR ICAT, Angers, France.
Abstract:
Fungal infections are increasing globally, with limited antifungal classes, drug toxicity issues, and the rapid emergence of multidrug resistance (MDR). By using a glycosyltransferase phylogeny-guided strategy, Deng and colleagues recently identified a new broad-spectrum polyene macrolide active against many fungal pathogens, with a novel mechanism of action and excellent safety profile.
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