Related Experiment Video

Updated: May 11, 2026

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
08:54

Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds

Published on: February 14, 2018

Innovation in antifungal therapy

Sarah Dellière1,2, Nicolas Papon3

  • 1Université Paris Cité, AP-HP, Parasitology-Mycology Department, Groupe Hospitalier Saint-Louis-Lariboisière-Fernand-Widal, Paris, France. sarah.delliere@aphp.fr.

EMBO Molecular Medicine
|May 9, 2026
PubMed

Insights

Invasive fungal infections are a growing public health concern, especially for immunocompromised patients. Advances in antifungal therapies offer new hope for managing these challenging infections and combating drug resistance.

Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Immunology

Background:

  • Invasive fungal infections (IFIs) pose a significant public health threat, particularly in immunocompromised individuals.
  • High mortality rates (often >50%) and limited systemic antifungal options complicate patient management.
  • Emerging antifungal resistance due to overuse/misuse in clinical and agricultural settings exacerbates the challenge.

Purpose of the Study:

  • To review recent advances in antifungal therapies for invasive fungal infections.
  • To highlight progress in both pathogen-directed and host-directed treatment strategies.
  • To underscore the need for novel approaches to combat rising IFIs and resistance.

Main Methods:

  • Review of recent literature on medical mycology and antifungal drug development.
  • Analysis of pathogen-directed therapies including new compounds, drug repurposing, and novel targets.
  • Exploration of emerging host-directed immunomodulatory strategies.

Main Results:

  • Significant advancements in identifying new antifungal compounds and drug targets.
  • Development of new formulations and repurposing of existing drugs show promise.
  • Emerging host-directed therapies leveraging immune responses offer new avenues for treatment.

Conclusions:

  • Despite challenges, recent breakthroughs in medical mycology provide hope for improved management of invasive fungal infections.
  • A combination of advanced pathogen-directed and novel host-directed strategies is crucial.
  • Continued research is essential to overcome antifungal resistance and reduce IFI-related mortality.

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