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[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Nickel-Catalyzed Reductive Alkylation of Pyridines via C-N Bond Activation
Ya-Xin Yu1, Jia-Fan Qiao1, Tian-Zhang Wang1
1School of Chemistry and Chemical Engineering, Shandong University, Jinan, Shandong 250100, China.
Abstract:
In this work, we utilized 2-pyridylpyridones as substrates for a reductive transformation with alkyl bromides via C-N bond activation through a Ni-catalyzed cross-electrophile coupling platform to efficiently construct 2-alkylpyridines at room temperature. The reaction allowed the use of a variety of sensitive electronic substituents on both coupling agents. Yields up to 95% can be achieved using a wide array of pyridylpyridones as pyridyl precursors. In addition, applications in the late-stage functionalization of natural products and drugs enhanced its potential.
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