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Related Concept Videos

Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Multipotency of Hematopoietic Stem Cells01:19

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The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
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Related Experiment Video

Updated: Jun 16, 2025

Intracellular Staining and Flow Cytometry to Identify Lymphocyte Subsets within Murine Aorta, Kidney and Lymph Nodes in a Model of Hypertension
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Association of Immune Cell Subsets With Longevity: The Cardiovascular Health Study.

Sylvie Dobrota Lai1, Petra Buzkova2, Joseph A Delaney3,4

  • 1Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford, California, USA.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
|May 16, 2025
PubMed
Summary

Certain immune cells, like CD4+CD57+ cells, are linked to earlier death, especially in males. This finding sheds light on aging and immune system changes.

Keywords:
BiomarkersInflammationRisk factors

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Area of Science:

  • Immunology and Gerontology: Investigating the intersection of immune system function and the aging process.

Background:

  • Immune system changes are a key biological aspect of aging.
  • Research is needed to understand how circulating immune cell subsets relate to mortality and longevity.

Purpose of the Study:

  • To examine the association between specific immune cell subsets and age at death.
  • To determine the relationship between immune cell phenotypes and survival to age 90.

Main Methods:

  • Analysis of immune cell phenotypes in 1,625 older adults (aged 70-85) from the Cardiovascular Health Study.
  • Utilized linear regression and Poisson models, adjusting for covariates, and tested for sex and race interactions.
  • Investigated 23 secondary immune cell subsets with Holm-Bonferroni correction for multiple comparisons.

Main Results:

  • No primary immune cell subsets showed a significant association with longevity.
  • Higher proportions of CD4+CD57+ cells and CD4+CD28-CD57+ cells were associated with earlier death.
  • CD4+CD57+ T-cells showed a stronger association with earlier death and reduced survival to 90 in males compared to females.

Conclusions:

  • CD4+CD57+ cells are implicated in earlier mortality.
  • The association between CD4+CD57+ cells and mortality risk is more pronounced in males.