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![Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg&w=3840&q=50)
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Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate [18F]SFB
Published on: June 28, 2011
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Two-step electrochemically driven synthesis of sunitinib
Anita Alni1, Robby Gus Mahardika1,2, Ade Danova1
1Organic Chemistry Division Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jl. Ganesa No. 10, Bandung, West Java 40132, Indonesia. alni@itb.ac.id.
Organic & Biomolecular Chemistry
|May 19, 2025
Summary
This study presents a novel electrochemical sunitinib synthesis using iodide mediation. This green chemistry approach achieves high yields for amidation and condensation reactions at room temperature.
Area of Science:
- Organic Chemistry
- Electrochemistry
- Green Chemistry
Background:
- Conventional sunitinib synthesis methods often involve harsh conditions and generate significant waste.
- There is a growing need for sustainable and environmentally friendly synthetic routes in pharmaceutical manufacturing.
Purpose of the Study:
- To develop a novel electrochemical method for sunitinib synthesis.
- To investigate the use of iodide as a mediator in electrochemical reactions.
- To explore the potential of graphite electrodes for sustainable synthesis.
Main Methods:
- Electrochemical synthesis utilizing iodide as a mediator.
- Amidation and condensation reactions performed at room temperature.
- Utilized graphite electrodes as the electrode material.
Main Results:
- Achieved a 72% yield for the amidation step.
- Achieved a 95% yield for the condensation step.
- Demonstrated the crucial role of iodide in the reaction mechanism.
Conclusions:
- The developed electrochemical method offers a sustainable and efficient route for sunitinib synthesis.
- Iodide acts as a key mediator, facilitating the reactions under mild conditions.
- Graphite electrodes represent a viable eco-friendly alternative for electrochemical synthesis.
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