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Botulism Type F: Foodborne or Adult Intestinal Colonization?

Idean Pourshams1,2, Pradeep Kumbham1,2, Srikar Ranga3,4

  • 1Department of Internal Medicine, University of Arkansas for Medical Sciences, Fayetteville, Arkansas.

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|May 19, 2025
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Summary

A rapid-onset paralysis case, suspected as an allergic reaction, was diagnosed as botulism type F. Prompt antitoxin treatment led to near-complete recovery, highlighting the importance of timely diagnosis for this neurotoxin.

Keywords:
BotulismFoodborneParalysisSemaglutideType F

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Area of Science:

  • Neurology
  • Toxicology
  • Infectious Diseases

Background:

  • Botulism is a rare but serious paralytic illness caused by botulinum neurotoxins.
  • Early diagnosis and treatment are crucial for patient outcomes.

Observation:

  • A 45-year-old woman presented with symptoms mimicking an allergic reaction, rapidly progressing to cranial nerve palsies and descending muscle weakness.
  • The patient required mechanical ventilation due to respiratory compromise.

Findings:

  • Botulinum neurotoxin type F was identified in the patient's serum.
  • The patient experienced a severe paralytic course but achieved near-complete recovery after several weeks of intensive care and rehabilitation.
  • The clinical presentation and recovery pattern were consistent with previously reported cases of botulism type F.

Implications:

  • This case underscores the importance of considering botulism in patients with rapidly progressing paralysis, even with atypical initial presentations.
  • Prompt administration of botulism antitoxin can significantly improve patient outcomes.
  • Further investigation into the source of botulism (foodborne vs. adult intestinal toxemia) is critical for public health surveillance and prevention efforts.