High-efficiency microfluidic chip integrated with micro-patterned planar spiral sensors for magnetic nanoparticle
Nguyen Van Tuan1, Ho Anh Tam2, Nguyen Thi Ngoc3
1Department of Physics, Le Quy Don Technical University, Hanoi 100000, Vietnam.
Lab on a Chip
|May 19, 2025
Summary
This study presents a novel planar magnetoimpedance sensor for detecting magnetic nanoparticles within microfluidic systems. The sensor offers high sensitivity and cost-effectiveness for biological concentration detection.
Area of Science:
- Biomedical Engineering
- Materials Science
- Sensor Technology
Background:
- Magnetic nanoparticles (MNPs) are vital in biomedicine, but their quantification is challenging.
- Current MNP detection methods require complex magnetic sensors and integration into microfluidic platforms.
Purpose of the Study:
- To develop an innovative planar magnetoimpedance (MI) sensor for sensitive MNP detection.
- To integrate the MI sensor into a microfluidic channel for enhanced MNP quantification.
- To optimize sensor design using micromagnetic simulations.
Main Methods:
- Micromagnetic simulations were used to optimize spiral micropatterns (70-210 μm width).
- A planar MI sensor was fabricated using wet chemical etching of an FeSiC ribbon.
- The sensor was integrated into a microfluidic channel for MNP detection.
Main Results:
- Optimal sensor design achieved a sensitivity of 2.5% Oe⁻¹ and resolution of 0.01 Oe.
- The integrated system successfully detected MNPs down to 0.2 μg.
- MI sensor output correlated with transverse magnetic domain configurations and stray fields.
Conclusions:
- The developed MI sensor integrated with microfluidics offers a cost-effective, rapid, and user-friendly method for MNP detection.
- This technology shows significant potential for biological concentration detection and advanced research.
- The study highlights the influence of magnetic domain configurations on MI sensor performance.
