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Updated: May 23, 2025

Intranasal Administration of CNS Therapeutics to Awake Mice
Published on: April 8, 2013
Intranasal insulin enhances resting-state functional connectivity in Type 2 Diabetes.
Zongpai Zhang1, Vera Novak2, Peter Novak3
1School of Computing, State University of New York at Binghamton, Binghamton, New York, United States of America.
Intranasal insulin (INI) improved brain connectivity in type 2 diabetes patients. INI treatment modulated resting-state functional connectivity (rsFC) in key brain regions, offering potential for cognitive decline treatment.
Area of Science:
- Neuroscience
- Endocrinology
- Radiology
Background:
- Type 2 diabetes mellitus (T2DM) negatively impacts cognitive function and brain connectivity.
- Intranasal insulin (INI) is being investigated as a therapeutic strategy for T2DM-related cognitive impairment.
Purpose of the Study:
- To assess the impact of INI on resting-state functional connectivity (rsFC) in T2DM patients.
- To explore the relationship between rsFC changes, cognitive function, HbA1c, HOMA-IR, and walking speed.
Main Methods:
- A 24-week MRI sub-study of the MemAID trial involving intranasal insulin (INI) or placebo.
- fMRI scans acquired at baseline and end-of-treatment in T2DM subjects.
- Analysis of rsFC between medio-prefrontal cortex (mPFC), hippocampus (lHPC/rHPC), and other brain regions.
Main Results:
- INI treatment significantly increased rsFC between mPFC and postcentral gyrus, and between hippocampus and frontal/postcentral regions.
- INI also enhanced connectivity between the left hippocampus and mPFC.
- Decreased HOMA-IR correlated with increased mPFC-basal ganglia rsFC.
Conclusions:
- INI treatment demonstrates potential to modulate brain functional connectivity in T2DM.
- Observed rsFC changes may underlie cognitive improvements and metabolic benefits in T2DM.
- Further validation in larger trials is warranted to confirm these findings.
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