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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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Proteotranscriptomics Analysis Reveals the Key Pathways and Genes Involved in Apigenin's Anti-Liver Fibrosis Effects.

Tao Sun1, Xiuzhi Zhang1, Xianghua Liu2

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Apigenin shows promise in treating liver fibrosis by reversing key molecular changes. This study used advanced multiomics to identify potential therapeutic targets and biomarkers for liver fibrosis progression.

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apigeninliver fibrosismolecular mechanismsproteotranscriptomicstherapeutic potential

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Hepatology

Background:

  • Liver fibrosis is a significant global health concern with few effective treatments.
  • The precise mechanisms by which apigenin exerts its protective effects against liver fibrosis are not fully understood.

Purpose of the Study:

  • To elucidate the molecular mechanisms of apigenin's antifibrotic effects using an integrated proteotranscriptomic approach.
  • To identify potential therapeutic targets and biomarkers for liver fibrosis.

Main Methods:

  • Carbon tetrachloride (CCl4)-induced liver fibrosis model in mice.
  • Transcriptomic and proteomic analyses of liver tissues from mice treated with varying doses of apigenin.
  • Correlation analysis of gene and protein expression with fibrosis severity in mouse and human datasets.

Main Results:

  • Apigenin demonstrated dose-dependent antifibrotic effects.
  • Identified 82 biological processes inversely regulated by CCl4 and apigenin at both mRNA and protein levels.
  • Discovered six key proteins consistently correlated with fibrosis severity across mouse and human data, indicating translational potential.

Conclusions:

  • Apigenin possesses significant therapeutic potential for liver fibrosis.
  • Integrated multiomics approaches are crucial for understanding complex diseases like liver fibrosis.
  • Identified key proteins serve as potential biomarkers and therapeutic targets for fibrosis progression.