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Updated: May 23, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Electrochemical Aryl(alkyl)thiolation on α-C-H Bond of Ethers to Access O,S-Acetals
Mengyun Wu1, Mingqi Chen1, Wenhui Wang1
1School of Chemistry and Materials Science, Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University, Nanjing 210023, China.
Abstract:
The efficient construction of a C-S bond is one of the important topics in organic synthesis. In this work, a cross-dehydrogenative coupling reaction between ether and thiophenols or thiols under electrochemical conditions was studied, and the acetal-O,S products were obtained in moderate to good yields. A free radical coupling mechanism was proposed. The reaction provided a simple protocol for the formation of C(sp3)-S bonds under transition-metal- and chemical oxidant-free conditions, and will have a good application prospect in organic synthesis and drug synthesis.
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