Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skeletal Muscle Relaxants: Adverse Effects01:21

Skeletal Muscle Relaxants: Adverse Effects

327
Skeletal muscle relaxants are widely used for muscle paralysis and relieving pain following any muscle injury or stiffness. However, depending on the drug type, they can have adverse effects that range from mild to severe. Usually, nondepolarizing neuromuscular blockers have minimal side effects. For example, drugs like d-tubocurarine, cisatracurium, and rocuronium cause hypotension, whereas drugs like baclofen, when stopped abruptly, can lead to the recurrence of spastic conditions.
Unlike...
327
Mania and Antimanic Drugs: Overview01:24

Mania and Antimanic Drugs: Overview

106
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
106

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Simulation based learning as a strategy for patient education training in medical students.

Scientific reports·2026
Same author

Social Context Considerations for Future HIV Vaccine Introduction and Implementation.

Vaccines·2026
Same author

Complications and outcomes of children under one year treated with continuous kidney replacement therapy.

Pediatric nephrology (Berlin, Germany)·2026
Same author

Persistent Hypoxia After Tricuspid Valve Replacement.

JACC. Case reports·2026
Same author

Building Trust and Engaging Communities for HIV Prevention Research Globally.

AIDS education and prevention : official publication of the International Society for AIDS Education·2026
Same author

Time in Tight Range Versus Time in Range for Predicting Diabetic Retinopathy in Adults with Type 1 Diabetes Using Multiple Daily Insulin Injections: A Retrospective Longitudinal Study with isCGM Data.

Diabetes technology & therapeutics·2025

Related Experiment Video

Updated: May 23, 2025

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

18.1K

Magnesium disturbances in critically ill children.

Selma Amar1, Sofia Martín Acedo1, Santiago Rodríguez-Tubio2

  • 1Mother and Child and Public Health Department, School of Medicine, Complutense University of Madrid, Madrid, Spain.

Scientific Reports
|May 21, 2025
PubMed
Summary

Magnesium disturbances are common in the Paediatric Intensive Care Unit (PICU). Hypomagnesemia is linked to acute kidney injury, shock, ECMO, and increased mortality in critically ill children.

Keywords:
Acute kidney injuryCardiac surgeryHypermagnesemiaHypomagnesemiaMechanical ventilationShock

More Related Videos

Studying Brain Function in Children Using Magnetoencephalography
08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.0K
Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children
04:55

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Published on: September 11, 2018

10.6K

Related Experiment Videos

Last Updated: May 23, 2025

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure
15:18

Making MR Imaging Child's Play - Pediatric Neuroimaging Protocol, Guidelines and Procedure

Published on: July 30, 2009

18.1K
Studying Brain Function in Children Using Magnetoencephalography
08:00

Studying Brain Function in Children Using Magnetoencephalography

Published on: April 8, 2019

9.0K
Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children
04:55

Handheld Metal Detector Screening for Metallic Foreign Body Ingestion in Children

Published on: September 11, 2018

10.6K

Area of Science:

  • Pediatric Critical Care Medicine
  • Pediatric Endocrinology
  • Pediatric Nephrology

Background:

  • Magnesium is crucial for cellular function, and its disturbances are frequently observed in critically ill patients.
  • Understanding the prevalence and impact of magnesium imbalances in pediatric intensive care is essential for improving patient outcomes.

Purpose of the Study:

  • To determine the incidence of magnesium disturbances (hypomagnesemia and hypermagnesemia) in children admitted to a Pediatric Intensive Care Unit (PICU).
  • To investigate the association between these magnesium disturbances and clinical complications, including acute kidney injury (AKI), shock, extracorporeal membrane oxygenation (ECMO) use, and mortality.

Main Methods:

  • A single-center, observational, retrospective study was conducted.
  • Serum magnesium levels, clinical data, severity scores (FSS, PRISM, P-LOF, P-MODS), and outcomes were analyzed for 200 children admitted to the PICU.
  • Prevalence of initial and in-admission hypomagnesemia and hypermagnesemia was assessed and correlated with clinical parameters and outcomes.

Main Results:

  • Hypomagnesemia was present initially in 3% and during admission in 13% of children.
  • In-admission hypomagnesemia was significantly associated with AKI (p=0.038), shock (p=0.003), and ECMO (p=0.046).
  • Patients with hypomagnesemia experienced higher mortality (15.4% vs. 1.7%, p=0.006).
  • Hypermagnesemia was observed initially in 32% and during admission in 44.5% of children.
  • In-admission hypermagnesemia was linked to cardiac surgery (p<0.001) but not mortality (p=0.702).

Conclusions:

  • Magnesium disturbances, both hypomagnesemia and hypermagnesemia, are prevalent in PICU admissions.
  • In-hospital hypomagnesemia is a significant predictor of severe complications and mortality in critically ill children.
  • Hypermagnesemia is associated with cardiac surgery but does not appear to impact mortality in this cohort.