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Updated: May 23, 2025

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
Published on: February 14, 2017
[The tricuspid: the valve we can no longer forget]
Sarah Mauler-Wittwer1, Georgios Giannakopoulos1,2, Marc Arcens1,3
1Unité de cardiologie structurelle, Service de cardiologie, Département de médecine, Hôpitaux universitaires de Genève, 1211 Genève 14.
Abstract:
The prevalence of tricuspid regurgitation (TR) increases with age and female sex. Ventricular dysfunction, splanchnic overload, renal failure, and liver congestion contribute to its morbi-mortality. The most common etiology of TR is secondary to right atrial or ventricular dilatation. The TRI-SCORE, a risk score assessing the intrahospital mortality of isolated TR surgery, should be available in the heart team discussion. Surgical valve repair improves survival with low or intermediate TRI-SCORE, but not with high TRI-SCORE. Transcatheter repair and replacement showed TR reduction and improved life quality scores, but without differences in death or heart failure hospitalizations. TR intervention should be performed before the disease is too advanced (low or intermediate TRI-SCORE).
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