Retinol-Augmented PRF Versus PRF Alone in Periodontal Regeneration: A Randomized Clinical Trial

Area of Science:

• Periodontology
• Regenerative Medicine
• Biomaterials

Background:

• Periodontitis, particularly stage-III grade B, presents significant challenges in treating intraosseous defects.
• Masticatory Mucosa Interpositional Tunneling Surgery (M-MIST) is a technique used for periodontal regeneration.
• Platelet-rich fibrin (PRF) is a biomaterial investigated for its regenerative potential in dentistry.

Purpose of the Study:

• To compare the efficacy of vitamin A-supplemented integrated platelet-rich fibrin (VitA/i-PRF) versus integrated platelet-rich fibrin (i-PRF) alone in treating periodontal intraosseous defects.
• To evaluate the clinical and radiographic outcomes of M-MIST when combined with VitA/i-PRF or i-PRF.

Main Methods:

• A study involving patients with stage-III grade B periodontitis and periodontal intraosseous defects.
• Application of M-MIST procedure with either VitA/i-PRF or i-PRF.
• Assessment of clinical parameters and radiographic bone fill at 6 and 9 months post-treatment.

Main Results:

• Both VitA/i-PRF and i-PRF groups demonstrated improvements in clinical and radiographic outcomes.
• VitA/i-PRF showed a minor, though not statistically significant, advantage in reducing defect depth and increasing bone fill at the 6-month follow-up.
• The observed benefits of VitA/i-PRF were not sustained, with diminishing effects noted by the 9-month assessment.

Conclusions:

• Both VitA/i-PRF and i-PRF are effective in improving outcomes for M-MIST in periodontal intraosseous defects.
• While VitA/i-PRF may offer a transient, non-significant enhancement in early bone regeneration, its long-term advantage over i-PRF alone is not clinically evident at 9 months.