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Creating A Course Based Undergraduate Research Experience (CURE) Genetics Yeast Laboratory Course at Xavier
Joanna E Haye-Bertolozzi1, Cecily B DeFreece1, Christopher Bolden1
1Xavier University of Louisiana, Department of Biology, New Orleans, Louisiana, USA.
Summary
This Genetics Laboratory course-based undergraduate research experience (CURE) provided 595 students authentic research skills. Students investigated Msh6 variants' effects on DNA mismatch repair using Saccharomyces cerevisiae.
Area of Science:
- Genetics
- Molecular Biology
- Biochemistry
Background:
- Course-based undergraduate research experiences (CUREs) offer authentic research opportunities.
- Integrating research into coursework enhances scientific skill development.
- DNA mismatch repair (MMR) is crucial for genomic stability.
Purpose of the Study:
- To implement a Genetics CURE course at Xavier University of Louisiana.
- To investigate the impact of Msh6 missense variants on DNA mismatch repair (MMR).
- To foster scientific communication skills among undergraduates.
Main Methods:
- Developed and implemented a Genetics Laboratory CURE.
- Utilized Saccharomyces cerevisiae as a model organism.
- Students analyzed uncharacterized MSH6 alleles and MMR pathways.
Main Results:
- 595 students participated in the CURE over three years.
- Students drafted research articles and delivered presentations.
- Course evaluations showed high student appreciation for research-context learning.
Conclusions:
- The Genetics CURE successfully provided authentic research experiences.
- Students gained practical skills in molecular genetics and scientific communication.
- CUREs are effective in enhancing science education through hypothesis-driven research.
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