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Updated: Dec 25, 2025

Microfluidic Production of Lysolipid-Containing Temperature-Sensitive Liposomes

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Published on: March 3, 2020

Ciprofloxacin-loaded electrosprayed lactose particles.

Sai Liu¹, Simon Gaisford¹, Gareth R Williams¹

¹UCL School of Pharmacy, University College London, 29 - 39 Brunswick Square, London WC1N 1AX, UK.

International Journal of Pharmaceutics

|May 24, 2025

Summary

This summary is machine-generated.

Electrospraying created lactose microparticles loaded with ciprofloxacin (cipro) for bacterial infections. These particles showed rapid drug release and effective antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa.

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Area of Science:

Pharmaceutical Sciences
Materials Science

Background:

Bacterial infections remain a significant global health concern.
Advanced drug delivery systems are crucial for combating these infections.

Purpose of the Study:

To explore electrospraying for producing lactose microparticles loaded with ciprofloxacin.
To optimize the electrospraying process for enhanced particle formation using polyvinyl alcohol (PVA).

Main Methods:

Electrospraying technique was employed to fabricate lactose microparticles.
Polyvinyl alcohol (PVA) was used as an additive to improve particle formation.
Ciprofloxacin loading and release kinetics were analyzed.

Main Results:

Spherical electrosprayed (ES) lactose microparticles with ciprofloxacin loadings from 0.25% to 1.07% w/w were successfully produced.
ES particles were amorphous and contained residual water.
Rapid drug release was observed within 5 hours.
Concentration-dependent antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa was demonstrated.

Conclusions:

Electrospraying is a viable method for producing ciprofloxacin-loaded amorphous lactose microparticles.
The developed ES particles show potential for treating acute bacterial infections due to rapid drug release and potent antibacterial effects.