Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in histamine turnover in the brain of spontaneously hypertensive rats.

R Oishi, Y Itoh, M Nishibori

    Brain Research
    |September 16, 1985
    PubMed
    Summary

    Brain histamine turnover is reduced in hypertensive rats, especially in key brain regions. Supplementation with L-histidine did not impact hypertension development in these models.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Association of low back pain and sleep quality with presenteeism.

    Occupational medicine (Oxford, England)·2022
    Same author

    Evaluation of epithelial and mesenchymal cell markers in canine urinary bladder transitional cell carcinoma.

    Veterinary journal (London, England : 1997)·2020
    Same author

    Rapid production of fertile transgenic barley (Hordeum vulgare L.) by direct gene transfer to primary callus-derived protoplasts.

    Plant cell reports·2019
    Same author

    Expression of the Short Form of RON/STK in Feline Mammary Carcinoma.

    Veterinary pathology·2018
    Same author

    Adjunctive perampanel in partial-onset seizures: Asia-Pacific, randomized phase III study.

    Acta neurologica Scandinavica·2017
    Same author

    Pharmacokinetic/pharmacodynamic analysis of adjunctive perampanel in subjects with partial-onset seizures.

    Acta neurologica Scandinavica·2017

    Area of Science:

    • Neuroscience
    • Cardiovascular Research
    • Pharmacology

    Background:

    • Hypertension is a complex condition with multifactorial origins.
    • The role of neurotransmitters, including histamine, in blood pressure regulation is an area of ongoing research.
    • Spontaneously hypertensive rats (SHR) are a widely used animal model for studying hypertension.

    Purpose of the Study:

    • To investigate histamine (HA) turnover rates in the brain of spontaneously hypertensive rats (SHR).
    • To determine the effect of chronic L-histidine treatment on the development of hypertension in SHR.
    • To explore the potential link between altered brain HA turnover and the pathogenesis of hypertension.

    Main Methods:

    • Histamine turnover rate was assessed by measuring the accumulation of tele-methylhistamine.

    Related Experiment Videos

  • Pargyline treatment was administered to inhibit monoamine oxidase activity.
  • Measurements were compared between SHR and normotensive Wistar Kyoto rats.

    • Main Results:

    • Histamine turnover rates were significantly lower in SHR compared to Wistar Kyoto rats.
    • Reduced HA turnover was particularly pronounced in the hypothalamus and brainstem regions of SHR.
    • Chronic L-histidine administration did not alter the progression of hypertension in SHR.

    Conclusions:

    • Brain histamine turnover is decreased in spontaneously hypertensive rats.
    • The reduced histamine turnover may be implicated in the development or maintenance of hypertension.
    • L-histidine supplementation does not appear to be a viable therapeutic strategy for hypertension in this model.