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PISA printing perfusable microcapillaries.

Aaron Priester1, Jimmy Yeng1, Yuwei Zhang2

  • 1Department of Materials Science and Engineering, Missouri University of Science and Technology, 1400 North Bishop Avenue, Rolla, MO 65409, USA. convertinea@mst.edu.

Biomaterials Science
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Summary
This summary is machine-generated.

This study introduces a simplified PISA printing method using multi-CTA scaffolds for fabricating complex 3D structures. The technique enables precise control over nanoscale features and creates robust, dissolvable networks for advanced microfabrication.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Microfabrication

Background:

  • Polymerization-induced self-assembly (PISA) printing integrates reversible addition-fragmentation chain transfer (RAFT) polymerization and digital light projection (DLP) photolithography.
  • Existing methods often require complex synthesis and purification steps for creating 3D polymer structures.

Purpose of the Study:

  • To develop a simplified, one-pot, purification-free synthesis for multi-chain transfer agent (multi-CTA) scaffolds for PISA printing.
  • To demonstrate precise control over nanoscale morphologies and selective distribution behaviors in printed structures.
  • To showcase the fabrication of functional microdevices using this enhanced PISA printing approach.

Main Methods:

  • Utilized a one-pot synthesis for multi-CTA scaffolds, eliminating purification steps.
  • Employed PISA printing by combining RAFT polymerization with DLP photolithography.
  • Tuned solvent-resin chemistry and polymer composition to control material properties and printing outcomes.

Main Results:

  • Successfully synthesized multi-CTA scaffolds that form spontaneous, robust physical networks during printing.
  • Achieved precise control over nanoscale morphologies and selective distribution behaviors by adjusting material parameters.
  • Fabricated perfusable microvascular networks and open-channel polydimethylsiloxane (PDMS) microfluidic devices with stable microchannels after scaffold dissolution.

Conclusions:

  • The simplified PISA printing approach enhances accessibility, flexibility, and functionality for microfabrication.
  • This adaptable platform is suitable for rapid prototyping and advanced tissue engineering applications.
  • The developed method offers an efficient route to creating complex, high-resolution 3D polymer structures without permanent crosslinks.