Related Experiment Video
Updated: Jul 10, 2025
06:02
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
Published on: June 12, 2021
3.9K
Gas Vesicle-Blood Interactions Enhance Ultrasound Imaging Contrast
Bill Ling1, Jeong Hoon Ko1, Benjamin Stordy2,3
1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States.
Nano Letters
|November 20, 2023
Summary
Gas vesicles (GVs) interact with blood cells and proteins, affecting their use in medicine. Modifying GV surfaces can improve their performance for nanomedicine applications.
Area of Science:
- Biotechnology
- Nanomedicine
- Biophysics
Background:
- Gas vesicles (GVs) are protein nanostructures with potential biomedical applications.
- Understanding GV interactions with blood components is crucial for their in vivo use.
Purpose of the Study:
- To investigate the dynamics of GVs in the bloodstream.
- To determine how blood components affect GV behavior.
- To explore surface modification strategies to enhance GV performance.
Main Methods:
- Ultrasound and optical imaging
- Surface functionalization techniques
- Flow cytometry and mass spectrometry
Main Results:
- Erythrocytes and serum proteins bind to GVs.
- This binding influences GV acoustic response, circulation time, and immunogenicity.
- Surface modification alters GV-blood component interactions and in vivo performance.
Conclusions:
- GV interactions with blood components are critical for their nanomedicine applications.
- Surface engineering offers a route to optimize GV behavior for improved in vivo performance.
- These findings provide essential insights for developing GVs as therapeutic and imaging agents.
Related Concept Videos
01:17Ultrasonography
4.5K
Ultrasonography is an imaging technique that uses high-frequency sound waves to visualize the body's internal structures. It is a non-invasive and safe procedure that does not involve the use of ionizing radiation, making it widely used in various medical fields. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development.
During an ultrasonography procedure, a handheld device called...
During an ultrasonography procedure, a handheld device called...
4.5K
01:20Imaging Studies for Cardiovascular System II:Types of Echocardiography
277
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
277