Preclinical Evaluation of a Novel Cryo Renal Denervation System
Florian Krackhardt1, Konstantinos Tsioufis2, Lucas Lauder3
1Deutsches Herzzentrum der Charité Universitätsmedizin Berlin, Klinik mit Schwerpunkt Kardiologie, Angiologie und Intensivmedizin, Berlin, Germany.
Abstract:
The objective of this study was to demonstrate the safety and efficacy of a novel cryo renal denervation system (Cryo-RDN) in a porcine model. Procedural and mid-term safety of the Cryo-RDN was demonstrated. Efficacy of the cryoablation was evidenced by histological findings in the renal arteries and reduced renal tissue norepinephrine concentrations on the treated sides. Despite some morphological nerve repair observed between 7 and 28 days, the greater renal norepinephrine suppression in the 28-day animals suggests irreversibly ablated sympathetic nerves.
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