Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

539
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
539
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

1.2K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
1.2K
Neural Regulation01:37

Neural Regulation

40.4K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
40.4K
Regulation of the Digestive System01:25

Regulation of the Digestive System

1.0K
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
1.0K
Global Regulatory Systems01:28

Global Regulatory Systems

86
Global regulatory systems in bacteria enable rapid and coordinated responses to environmental changes by integrating sensory inputs with gene expression, ensuring efficient adaptation to fluctuating conditions. Key global regulatory mechanisms include regulons, two-component systems, sigma factors, and secondary messengers.Regulons and Global RegulatorsA regulon is a collection of genes and operons controlled by a common global regulator. These regulators enable bacteria to prioritize resource...
86
Stringent Response in E. coli01:23

Stringent Response in E. coli

62
Bacterial growth is closely tied to nutrient availability, with cells proliferating exponentially under favorable conditions and entering a stationary phase when resources become scarce. This transition is mediated by a regulatory mechanism known as the stringent response, which allows bacteria to adapt to nutrient deprivation by modulating gene expression and metabolic activity.During nutrient scarcity, intracellular amino acid levels decline. It results in the accumulation of uncharged tRNAs...
62

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Senescent cells accumulate lipid droplets.

Aging·2026
Same author

Intratumoral B cells under stress.

Cancer cell·2026
Same author

Tumor-draining lymph nodes in ovarian cancer lack germinal centers but harbor tumor-reactive memory B cells clonally linked to intra-tumoral B cells.

Immunity·2026
Same author

Nasal germinal centers and IgA class-switch recombination depend on CCR6 and B cell receptor affinity.

The Journal of experimental medicine·2026
Same author

Inhibition of Tumor Microenvironment-Driven JAK-STAT Signaling Enhances Response to Arginine Deprivation Therapy in Triple-Negative Breast Cancer.

Cells·2026
Same author

p53 regulates the expression of histone modifiers to restrict stemness and maintain differentiated luminal identity in breast cancer.

Proceedings of the National Academy of Sciences of the United States of America·2025

Related Experiment Video

Updated: Sep 20, 2025

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

5.9K

A coordinated cellular network regulates tolerance to food.

Anna Rudnitsky1, Hanna Oh1, Maya Margolin1

  • 1Department of Systems Immunology, Weizmann Institute of Science, Rehovot, Israel.

Nature
|May 27, 2025
PubMed
Summary

New research reveals that RORγt+ cells, not conventional dendritic cells, induce food-specific regulatory T cells (pTreg). This pathway maintains gut tolerance, allowing temporary effector responses during infection without disrupting long-term food safety.

More Related Videos

Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

31.5K
Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

16.1K

Related Experiment Videos

Last Updated: Sep 20, 2025

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
16:26

Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes

Published on: August 20, 2007

5.9K
Isolation of Murine Lymph Node Stromal Cells
05:47

Isolation of Murine Lymph Node Stromal Cells

Published on: August 19, 2014

31.5K
Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation
15:33

Adenoviral Transduction of Naive CD4 T Cells to Study Treg Differentiation

Published on: August 13, 2013

16.1K

Area of Science:

  • Immunology
  • Gastroenterology
  • Microbiology

Background:

  • Host tolerance to dietary antigens and commensal microbes is crucial for nutrient absorption and gut health.
  • Peripheral regulatory T (pTreg) cells are key mediators of this immune tolerance.
  • Conventional type 1 dendritic cells (cDC1s) were previously thought to initiate dietary pTreg induction.

Purpose of the Study:

  • To identify the specific antigen-presenting cells responsible for inducing food-specific pTreg cells.
  • To elucidate the role of pTreg cells and cDC1s in regulating dietary CD8αβ T cell responses during homeostasis and infection.
  • To understand the immune circuit governing oral tolerance and its modulation during host challenges.

Main Methods:

  • Investigated the role of RORγt+ antigen-presenting cells (APCs) in inducing food-specific pTreg cells.
  • Analyzed the interaction between pTreg cells and cDC1s in regulating CD8αβ T cell expansion.
  • Examined the impact of infection and food poisoning on this regulatory circuit.

Main Results:

  • Food-specific pTreg cells are induced exclusively by RORγt+ APCs, not by cDC1s.
  • pTreg cell-cDC1 interactions during homeostasis suppress the expansion of food-specific CD8αβ T cells.
  • Infection disrupts this regulation, allowing transient expansion of dietary CD8αβ T cells with effector functions.
  • Following pathogen clearance, dietary CD8αβ T cells do not expand to food antigens, preserving tolerance.

Conclusions:

  • A distinct circuit involving RORγt+ APCs and T cells mediates tolerance to dietary antigens.
  • This circuit allows for transient protective effector responses during infection without compromising long-term oral tolerance.
  • Understanding this pathway is critical for maintaining gut homeostasis and safe food consumption.