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Updated: Jan 18, 2026

A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells
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A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells

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Optimizing homology-directed repair for gene editing: the potential of single-stranded DNA donors

Ying-Ying Jin1, Peng Zhang1, De-Pei Liu2

  • 1State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China.

Trends in Genetics : TIG
|May 28, 2025
PubMed

Keywords:
CRISPR–Cas systemcell and gene therapieshomology-directed repairprecise genome editingsingle-stranded DNA donor

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