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A fatal poisoning with LSD.

R R Fysh, M C Oon, K N Robinson

    Forensic Science International
    |June 1, 1985
    PubMed
    Summary
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    This study reports the first fatal poisoning case involving lysergic acid diethylamide (LSD). Analytical methods quantified LSD levels in biological samples from the deceased.

    Area of Science:

    • Forensic Toxicology
    • Analytical Chemistry

    Background:

    • Fatal poisoning cases are crucial for understanding drug toxicity.
    • Accurate quantification of substances in biological matrices is essential for forensic investigations.

    Purpose of the Study:

    • To report the first documented case of fatal poisoning by LSD.
    • To quantify LSD concentrations in various biological samples.

    Main Methods:

    • Radioimmunoassay (RIA) for initial detection.
    • High-performance liquid chromatography (HPLC) for separation and quantification.
    • Capillary gas chromatography-mass spectrometry (GC-MS) for definitive identification and quantification.

    Main Results:

    • LSD was detected and quantified in ante-mortem serum and plasma.

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  • Significant LSD levels were measured in post-mortem blood, liver blood, and stomach contents.
  • This case establishes a precedent for LSD-related fatalities.

    • Conclusions:

    • The analytical methods employed were effective in detecting and quantifying LSD in a fatal poisoning case.
    • This study provides critical data on LSD distribution in post-mortem samples.
    • Highlights the importance of advanced analytical techniques in forensic toxicology.