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Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Biopharmaceutics and Pharmacokinetics: Overview01:28

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Understanding drugs, drug products, and their performance in pharmaceutical science is pivotal. Drugs, whether simple molecules or complex compounds, are designed to interact with the body's biological systems to diagnose, treat, or prevent diseases. Drug products include various delivery systems such as tablets, capsules, injections, and inhalers. The performance of these drug products is gauged by their ability to deliver the active ingredient to the desired site of action at the...
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Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

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Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
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Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

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The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
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Drug Delivery: Overview01:16

Drug Delivery: Overview

430
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

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Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
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Solid-State Pharmaceutics Research in India: Present and Future.

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  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER), Sector-67, S. A. S. Nagar, Punjab 160062, India.

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Summary
This summary is machine-generated.

Indian pharmaceutical companies excel in generics but lag in high-revenue innovation. Enhancing solid-state pharmaceutics research and fostering academic-industry synergy can drive growth and economic impact.

Keywords:
APISSP clustercocrystalsformulationssolid-harmaceutics

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Area of Science:

  • Pharmaceutical Sciences
  • Drug Development
  • Materials Science

Background:

  • The pharmaceutical industry is vital for healthcare and national economies.
  • India is recognized as the "pharmacy of the world" for its generic drug production and supply chain capabilities.
  • Despite success in generics, the Indian pharmaceutical market valuation remains below $100 billion, contrasting with innovative global leaders.

Purpose of the Study:

  • To discuss prominent pharmaceutical research areas in Indian academia.
  • To analyze the current status and future prospects of solid-state pharmaceutics (SSP) and pharmaceutical crystal engineering research in India.
  • To emphasize the need for an improved research ecosystem to support pharmaceutical innovation.

Main Methods:

  • Review of prominent pharmaceutical research areas within Indian academic institutions.
  • Analysis of the evolution, current state, and future outlook of solid-state pharmaceutics research.
  • Exploration of the synergy between academic research and pharmaceutical companies for innovative outcomes.

Main Results:

  • Indian academia shows significant activity in various pharmaceutical research domains.
  • Solid-state pharmaceutics (SSP) research in India has evolved, but requires further development to match global standards.
  • A gap exists in translating academic research into high-revenue innovative pharmaceutical products.

Conclusions:

  • There is a critical need to enhance the research ecosystem for solid-state pharmaceutics in India.
  • Establishing a dedicated "solid-state pharmaceutics research cluster" is recommended to accelerate research.
  • Strengthening academic-industry collaborations is essential for fostering innovation and boosting the Indian pharmaceutical industry's economic contribution.