[Erythema toxicum neonatorum with pustulation versus transient neonatal pustular melanosis]

A girl with widespread vesicular pustular lesions present at birth is reported. The differential diagnosis is discussed, with an extreme eruption of erythema toxicum neonatorum and the newly described entity transient neonatal pustular melanosis (TNPM) under consideration. This benign, self-limited, pustular eruption, with lesions present at birth, requires no specific therapy, but must be distinguished from the neonatal skin manifestations of viral, bacterial and fungal diseases. The condition should not be confused with others involving sepsis.