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Updated: Jun 8, 2026

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Inducing Apical Periodontitis in Mice
Published on: August 6, 2019
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Microgravity Exacerbates Periodontitis In Vivo
Ahmed Bakri1, Asmaa Ismail2, Alaa Mansour1
1Periodontology Unit, College of Dental Medicine, University of Sharjah, UAE.
Journal of Periodontal Research
|May 31, 2025
Abstract
None:
This is the first study to examine induced periodontitis under simulated microgravity in vivo. Microgravity significantly increased alveolar bone loss, elevated GCF alkaline phosphatase levels, and caused severe periodontal destruction with notable immune cell infiltration. Understanding the underlying molecular pathways may guide future treatments for periodontitis in space and on Earth.

