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Progestin-only contraception and thrombosis: An updated systematic review

Naomi K Tepper1, Antoinette T Nguyen1, Maura K Whiteman1

  • 1Division of Reproductive Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, United States.

Contraception
|June 1, 2025
PubMed
Summary

Progestin-only contraception (POC) use, specifically depot medroxyprogesterone acetate (DMPA), may increase venous thromboembolism (VTE) risk in women with certain conditions. Other POCs do not appear to elevate VTE or arterial thromboembolism (ATE) risk.

Keywords:
ContraceptionProgestin-only contraceptionSystematic reviewThromboembolism

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