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Updated: Sep 19, 2025
Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
Observational study on Aspergillus infections in critically ill patients with coronavirus disease 2019 at a single
Rui-Ming Xu1, Xiao-Li Yuan1, Qing-Qing Ge1
1Department of Emergency, Beijing Tongren Hospital, Capital Medical University, Beijing, China 100176.
Objective:
To explore Aspergillus infection's risks, treatment, and prognostic factors in critically ill COVID-19 patients.
Methodology:
Retrospective analysis of 50 critically ill COVID-19 patients' data. Patients were divided into Aspergillus infection group (10 cases) and non-Aspergillus infection group (40 cases) to examine risk factors and compare hospitalization length, expenses, and survival outcomes.
Results:
Logistic regression showed a significant correlation between Aspergillus infection and diabetes history, and steroid use duration in COVID-19 patients. Diabetes increased Aspergillus infection risk 9.708 times (not statistically significant). Each extra steroid use day raised infection risk by 25.6%. The Aspergillus infection group had longer hospital stays, and higher costs (p < 0.05) but surprisingly higher survival rate than the non-infection group (p < 0.05).
Conclusions:
The main risk factor for Aspergillus infection in critically ill COVID-19 patients is steroid use duration. The infection group had longer hospital stays and higher costs, and Aspergillus infection affected the survival duration of critically ill COVID-19 patients.
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