The meta-Selective C-H Functionalization of Phenol Derivatives Using a Nitrile-Based Directing Group
Kurella Mounika1, Dasari Srinivas1, Gedu Satyanarayana1
1Department of Chemistry, Indian Institute of Technology Hyderabad, Kandi, Sangareddy, Telangana 502284, India.
None:
While ortho-C-H activation has been well explored, meta-C-H functionalization of phenols remains challenging due to regioselectivity constraints. Here, we introduce a site-selective meta-C-H olefination strategy using an aliphatic nitrile template under mild room-temperature conditions. This approach leverages nitrile-metal interactions to enable efficient C-H activation, overcoming the harsh conditions required in traditional methods. With a broad substrate scope and high efficiency, this method has been successfully applied to drug-like and natural product derivatives, delivering high yields and selectivities.
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