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Trogocytosis: revealing new insights into parasite-host interactions
Jia Shen1, Xuesong Li1, Geoff Hide2
1Department of Parasitology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, PR China; Key Laboratory of Tropical Disease Control of the Ministry of Education, Sun Yat-sen University, Guangzhou 510080, PR China; Provincial Engineering Technology Research Center for Biological Vector Control, Guangzhou 510080, PR China.
None:
Trogocytosis - a process whereby cells physically nibble and ingest membrane fragments and other components from neighboring cells - plays a critical role in host-parasite interactions by modulating parasite survival and host immune responses. This review explores trogocytosis in parasitic infections, revealing its dual roles: parasites use it for nutrient acquisition and immune evasion, whereas hosts use it for pathogen clearance. We analyze the molecular machinery driving this process, its impact on infection outcomes, and parallels in tumors/transplantation. Emerging therapeutic opportunities and unresolved challenges are critically evaluated, providing a roadmap for future research to harness trogocytosis in disease control.
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