Related Experiment Video
Updated: Sep 19, 2025

Author Spotlight: Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue
Published on: February 24, 2023
The ontogeny of synovial tissue macrophages
Joseph Hutton1,2, Wenrui Sun1,3, Tetsuo Hasegawa3
1Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom.
None:
Macrophages are essential components of all body tissues, including the synovium. Tissue macrophages originate either from embryonically seeded "primitive" macrophages or from bone marrow-derived monocytes. In adults, both sources contribute to macrophage populations, with their relative proportions varying across tissues and between steady-state and inflammation. Macrophages are highly responsive to microenvironmental and signalling cues, which significantly influence their function within tissues. This article reviews the current understanding of synovial tissue macrophage ontogeny in health and disease, highlighting knowledge gaps and potential avenues for future research.
More Related Videos
12:23Flow Cytometry Analysis of Immune Cell Subsets within the Murine Spleen, Bone Marrow, Lymph Nodes and Synovial Tissue in an Osteoarthritis Model
Published on: April 24, 2020
07:15In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
Published on: October 20, 2013
Related Concept Videos
Development of the Limb Synovial Joints
The mesenchymal stem cells differentiate into chondrocytes that form the hyaline cartilage, and later the cartilaginous model of the bone. This model further transforms into a bone. This process is known as endochondral ossification.
During development, the limbs...
Structural Joints: Synovial Joints
Inflammation
Growth of Cartilage and Bone Tissue
Immune Surveillance by NK Cells and Phagocytes
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Glycosaminoglycans
GAGS are found in the extracellular matrix of vertebrates, invertebrates, and bacteria. Due to their polar nature they attract water, and serve as excellent lubricants or shock absorbers in an animal body.
Hyaluronic...