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Updated: Sep 19, 2025
Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
Association between glycemic control indicators with renal function assessed by 99mTc-DTPA dynamic renal scintigraphy
Hang Su1,2, Jiaying Ni2, Danfeng Peng2
1Department of Gerontology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Purpose:
Our study aimed to analyze the impact of renal function, assessed by various methods of evaluating glomerular filtration rate (GFR), on glycated hemoglobin A1c (HbA1c), glycated albumin (GA), and 1,5-anhydroglucitol (1,5-AG).
Methods:
This cross-sectional study analyzed 5113 type 2 diabetes patients. GFR was evaluated using both 99mTc-DTPA dynamic renal scintigraphy (mGFR) and various estimating equations, including eGFRcr, eGFRcys, eGFRcr-cys, and eGFRc_MDRD.
Results:
Overall, the median or mean values of HbA1c, GA, serum 1,5-AG, and mGFR were 8.3 (7.2-9.8)%, 21.0 (17.5-25.9)%, 3.4 (1.8-7.1) μg/mL, and 88.3 ± 24.1 mL/min/1.73 m2, respectively. Multiple linear regression demonstrated that HbA1c and GA were not correlated with mGFR (both P > 0.05), but showed weak associations in all equations besides eGFRcys (β = 0.002-0.008, all P < 0.001). Serum 1,5-AG correlated mildly with all GFR measures (β = -0.016 to -0.048, all P < 0.001). When FPG and 2hPG were used as references for "actual" glucose level, significant and moderate associations were observed between HbA1c and GA with FPG (r = 0.324-0.649, all P < 0.001) and 2hPG (r = 0.341-0.592, all P < 0.001) across all CKD categories. Serum 1,5-AG maintained negative correlations with FPG and 2hPG (r = -0.239 to -0.463, all P < 0.001) in GFR ≥ 30 mL/min/1.73 m2, but not in GFR < 30 mL/min/1.73 m2. Results were consistent across all assessments using both mGFR and eGFR derived from the four equations.
Conclusion:
In subjects with mild-to-moderate renal insufficiency, HbA1c, GA, and serum 1,5-AG are reliable indicators of glucose control.
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