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Related Concept Videos

Acne Infection01:27

Acne Infection

94
Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
94

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Practical Algorithm on Topical Treatment of Flaring Atopic Dermatitis (AD) With or Without Secondary Infection.

Lawrence A Schachner, Adelaide A Hebert, Robert Sidbury

    Journal of Drugs in Dermatology : JDD
    |June 4, 2025
    PubMed
    Summary
    This summary is machine-generated.

    This study presents a new algorithm for managing atopic dermatitis (AD) flares, focusing on topical treatments for skin inflammation and Staphylococcus aureus (SA) infection. It highlights the need for multi-targeted therapies to improve patient outcomes.

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    Area of Science:

    • Dermatology
    • Clinical Practice Guidelines
    • Infectious Disease

    Background:

    • Atopic dermatitis (AD) flares are characterized by inflammation and often complicated by Staphylococcus aureus (SA) colonization or infection.
    • SA infection significantly contributes to AD exacerbations and impacts patient quality of life, leading to psychological distress.

    Purpose of the Study:

    • To develop a practice-based algorithm for the topical management of atopic dermatitis (AD) flares.
    • To provide clear guidance for dermatologists on treating flaring AD, with or without secondary S. aureus infection.

    Main Methods:

    • A systematic literature review was conducted to inform an expert panel.
    • Nine dermatology experts developed and refined a treatment algorithm through face-to-face and online discussions.
    • The algorithm focuses on topical treatments for both inflammation and infection in AD flares.

    Main Results:

    • The algorithm emphasizes a dual approach targeting skin inflammation and SA colonization/infection.
    • It identifies an unmet need for multi-targeted topical therapies for active and infected AD.
    • Zabalafin hydrogel is presented as a novel, investigational therapy for active AD flares.

    Conclusions:

    • The developed algorithm aims to optimize outcomes for AD patients, particularly those with frequent flares or secondary infections.
    • It stresses the importance of balancing therapeutic efficacy with antibiotic stewardship principles.
    • The guidance supports a comprehensive approach to managing complex AD cases.