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[Pleomorphic xanthoastrocytoma (Kepes): a case report]
No Shinkei Geka. Neurological Surgery
|July 1, 1985
Summary
This report details a pleomorphic xanthoastrocytoma (PXA) case in a 34-year-old female, presenting with a history of TIA and a temporal lobe tumor. The patient showed excellent recovery post-surgery and radiation, with no recurrence signs after five years.
Area of Science:
- Neuro-oncology
- Neuropathology
Background:
- Pleomorphic xanthoastrocytoma (PXA) is a rare glial tumor typically affecting younger patients.
- This case presents a PXA in a 34-year-old female, extending the known age range for this tumor type.
Observation:
- A 34-year-old female with a history of transient ischemic attacks (TIA) presented with a right temporal lobe lesion.
- Imaging revealed a well-defined low-density area with contrast enhancement.
- Surgical resection of the cystic tumor was performed, followed by radiation therapy.
Findings:
- Histological examination showed marked pleomorphism with minimal necrosis or mitosis, surrounded by reticulin fibers.
- Electron microscopy revealed glial fibrils and lipid granules.
- Immunoperoxidase staining confirmed glial fibrillary acidic protein (GFAP) and S-100 protein, indicating neuroectodermal origin.
Implications:
- This case expands the clinical and pathological spectrum of pleomorphic xanthoastrocytoma.
- The favorable 5-year outcome supports the diagnosis and effective treatment of PXA, even in older patients.
- This study contributes to understanding PXA's histological and immunohistochemical characteristics.