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Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells

Assaying Surface Expression of Chemosensory Receptors in Heterologous Cells

Published on: February 23, 2011

Organoid models for chemosensing cell studies.

Peihua Jiang¹, Nancy E Rawson¹

¹Monell Chemical Senses Center Philadelphia Pennsylvania United States.

American Journal of Physiology. Cell Physiology

|June 6, 2025

Summary

This summary is machine-generated.

Organoids, 3D miniature organ models, are revolutionizing chemosensory research. This review explores their use in studying taste and smell, highlighting future directions for this powerful in vitro tool.

Keywords:

olfactory organoids taste organoids

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Area of Science:

Biomedical Research
Developmental Biology
Organoid Technology

Background:

Organoids are 3D in vitro models mimicking organ structure and function.
Significant advancements have enabled organoid development for both regenerative and non-regenerative tissues.
Organoid models offer valuable platforms for diverse cell and tissue studies.

Purpose of the Study:

To review the establishment and application of organoid models derived from tissue stem/progenitor cells.
To focus on organoid models relevant to chemosensory cell studies, specifically taste and smell.
To discuss current limitations and future prospects of organoids in chemosensation research.

Main Methods:

Review of existing literature on organoid establishment and application.
Focus on organoids derived from tissue stem/progenitor cells.
Analysis of organoid utility in taste and smell research.

Main Results:

Organoids closely resemble native tissues in structure, function, and organization.
Organoid models are increasingly utilized across various scientific fields for in vitro studies.
Specific applications of organoids in chemosensory research are detailed.

Conclusions:

Organoid technology provides a powerful in vitro system for studying chemosensation.
Further development is needed to overcome limitations in current organoid models.
Future research directions aim to enhance the utility of organoids for taste and smell studies.