Closed-Loop Sulfur Dioxide Utilization in Photocatalytic Smiles Rearrangement.

Area of Science:

• Organic Chemistry
• Photocatalysis
• Green Chemistry

Background:

• Radical-mediated Smiles rearrangement is a key method for C-C bond formation.
• Existing methods often require harsh conditions or lack environmental sustainability.

Purpose of the Study:

• To develop a novel, environmentally benign photocatalytic Smiles rearrangement.
• To enable efficient synthesis of sulfone derivatives using sulfur dioxide.

Main Methods:

• Photocatalysis
• Radical cyclization and cleavage
• Closed-loop sulfur dioxide utilization

Main Results:

• Achieved efficient synthesis of sulfone derivatives.
• Demonstrated excellent compatibility with diverse substrates.
• Confirmed the crucial role of alkyl and sulfonyl radicals as intermediates.

Conclusions:

• The developed protocol offers an economical and green route to sulfones.
• This work expands the scope of photocatalytic Smiles rearrangements.
• Highlights the potential of closed-loop sulfur dioxide utilization in organic synthesis.