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Area of Science:

  • Supramolecular Chemistry
  • Organic Chemistry
  • Materials Science

Background:

  • Macrocyclic molecular receptors are crucial for supramolecular chemistry advancements.
  • Challenges remain in synthesis, aqueous performance, and stimuli-responsiveness of host-guest systems.

Purpose of the Study:

  • To develop a new family of self-assembled polycationic molecular rectangles.
  • To investigate their synthesis, aqueous performance, and molecular recognition properties.
  • To explore their potential as pH-responsive macrocyclic receptors.

Main Methods:

  • Modular synthesis via acid-catalyzed imine condensation in water.
  • Gram-scale synthesis achieving acceptable yields.
  • NMR spectroscopy to study aqueous molecular recognition with a model guest.

Main Results:

  • Successfully synthesized a new family of polycationic molecular rectangles with tunable dimensions.
  • Demonstrated efficient synthesis in water on a gram scale.
  • Observed formation of highly stable binary and ternary inclusion complexes in aqueous media.

Conclusions:

  • The new macrocyclic receptors exhibit tunable binding properties and excellent aqueous performance.
  • These pH-responsive receptors show significant potential for applications in host-guest chemistry.
  • The modular synthesis approach offers a highly efficient route to these novel compounds.