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Selected noble-gas partition coefficients.

M S Rosenthal, R J Nickles

    Physics in Medicine and Biology
    |September 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    This study measured the Ostwald solubility and bone-blood partition coefficients for Argon-41, Xenon (isotopes 127, 133), Nitrogen-13, and Fluorine-18 in various biological and non-biological tissues. Key findings include specific partition coefficients for Argon-41 and Xenon.

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    Area of Science:

    • Radiochemistry
    • Biophysics
    • Pharmacokinetics

    Background:

    • Accurate solubility and partition coefficients are crucial for understanding the distribution and behavior of radiopharmaceuticals in vivo.
    • In vitro measurements provide fundamental data for pharmacokinetic modeling and radiation dose calculations.

    Purpose of the Study:

    • To determine the Ostwald solubility of Argon-41 (41Ar), Xenon (127Xe, 133Xe), Nitrogen-13 (13N), and methyl [18F]fluoride (CH3 18F) in various media.
    • To measure the bone-blood partition coefficients for these radiotracers.
    • To provide essential data for nuclear medicine applications and safety assessments.

    Main Methods:

    • In vitro measurement of Ostwald solubility using the Ostwald method.
    • Determination of partition coefficients between bone and blood.

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  • Utilized diverse matrices including water, saline, blood, plasma, lipids, benzene, and bone.

    • Main Results:

    • Ostwald solubility was quantified for 41Ar, 127Xe, 133Xe, 13N, and CH3 18F across multiple solutions and tissues.
    • The bone-blood partition coefficient for 41Ar was determined to be 1.1 ± 0.3.
    • The bone-blood partition coefficient for Xenon isotopes was found to be 0.41 ± 0.1.

    Conclusions:

    • The study successfully quantified critical solubility and partition parameters for several important radiotracers.
    • These data are vital for accurate dosimetry and predicting the biodistribution of 41Ar, Xe, 13N, and 18F-labeled compounds.
    • The established bone-blood partition coefficients offer valuable insights into tracer localization in skeletal tissues.