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Monitoring the Assembly of a Secreted Bacterial Virulence Factor Using Site-specific Crosslinking
Published on: December 17, 2013
Cross-linking teichoic acids by click chemistry prevents bacterial cell growth
Morgane Baudoin1, Anne Chouquet2, Célia Boyat2
1Univ. Grenoble Alpes, CNRS, DPM, 38000 Grenoble, France. yung-sing.wong@univ-grenoble-alpes.fr.
None:
This work identifies a novel antibacterial mechanism that targets the cell wall of the human pathogen Streptococcus pneumoniae. Unlike conventional cell-wall targeting antibiotics, which inhibit the natural cross-linking of peptidoglycan, we introduce artificial cross-links in the other main component of the Gram-positive cell wall, the teichoic acids, and show that it leads to impaired cell growth.
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