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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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Liver disorders and phytotherapy.

Syed Sanober Qadri1, Darakhshan Javaid1, Adfar Reyaz1

  • 1Toxicology and Pharmacology Laboratory, Department of Zoology, School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, Jammu and Kashmir 185234, India.

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Medicinal plants show promise for liver health, offering natural compounds to combat liver diseases like ALD and NAFLD. This review explores their potential to overcome limitations of traditional treatments.

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Area of Science:

  • Hepatology and Pharmacology
  • Natural Product Chemistry

Background:

  • The liver is vital for metabolism and detoxification, but faces increasing threats from diseases like alcoholic liver disease (ALD), non-alcoholic fatty liver disease (NAFLD), and liver cancer.
  • Current treatments for liver conditions often face challenges including drug resistance, adverse side effects, and high costs, particularly in resource-limited settings.
  • Drug-induced liver injury (DILI) remains a significant clinical concern.

Purpose of the Study:

  • To review the mechanisms of liver injury.
  • To highlight the therapeutic potential of traditionally used medicinal plants in preventing and treating liver diseases.
  • To emphasize the integration of traditional medicine with modern pharmacological research.

Main Methods:

  • Literature review of scientific databases.
  • Analysis of studies on medicinal plants with reported hepatoprotective effects.
  • Examination of bioactive compounds and their pharmacological actions.

Main Results:

  • Numerous medicinal plants possess bioactive compounds such as alkaloids, glycosides, and flavonoids with demonstrated hepatoprotective properties.
  • These natural agents can mitigate hepatic damage, modulate immune responses, and aid in managing chronic liver conditions.
  • Traditional medicine offers a viable alternative or complementary approach to conventional therapies for liver diseases.

Conclusions:

  • Medicinal plants represent a promising source for novel hepatoprotective agents.
  • Integrating traditional knowledge with modern science can lead to effective and accessible treatments for liver diseases.
  • Further research is warranted to validate and develop plant-derived therapies for liver health.