Intramedullary Glioblastoma as One of Multiple Radiation-Induced Neoplasms
Kacper Koczyk1,2, Arkadiusz Nowak1, Marcin M Machnicki3
1Department of Neurosurgery, Central Clinical Hospital, Medical University of Warsaw, Warsaw, Poland.
Case Reports in Oncology
|June 9, 2025
Summary
This case report details a rare intramedullary glioblastoma in a patient with a history of radiation. Molecular analysis confirmed glioblastoma, IDH-wildtype (CNS WHO G4), highlighting the challenges in diagnosing spinal cord tumors.
Area of Science:
- Neuro-oncology
- Spinal cord tumors
- Radiation-induced neoplasms
Background:
- Intramedullary glioblastoma is a rare spinal tumor.
- Spinal cord gliomas can arise secondary to radiation therapy.
- Multiple neoplasms in a patient's history warrant thorough investigation.
Observation:
- A 53-year-old female presented with progressive spastic tetraparesis.
- Cervical MRI revealed an intramedullary lesion and a T1 vertebral body lesion.
- 18F-FDG-PET/CT showed increased uptake in the cervical spinal cord and T1 vertebral body.
Findings:
- Histomolecular analysis confirmed intramedullary glioblastoma, IDH-wildtype (CNS WHO G4).
- The T1 vertebral body lesion was identified as breast cancer metastasis.
- The patient experienced neurological decline post-surgery and died within 6 months.
Implications:
- This case underscores the complexity of diagnosing radiation-induced spinal cord tumors.
- Molecular profiling is crucial for accurate tumor classification.
- Understanding tumor origins aids in managing patients with complex oncological histories.
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