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Updated: Jun 12, 2025

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Artificial intelligence-based machine learning protocols enable quicker assessment of aortic biomechanics: A case
Pete H Gueldner1, Katherine E Kerr1, Nathan Liang1,2,3
1Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA.
Abstract:
Analyzing aortic biomechanical wall stresses for abdominal aortic aneurysms remains challenging. Clinical applications of biomechanical and morphological image-based analysis protocols have limited adoption owing to the time and expertise required. Our multidisciplinary and multi-institute team has demonstrated the feasibility of expediting advanced aortic image analysis on a single patient tracked longitudinally. We also demonstrate the utility of a previously trained artificial intelligence-based classifier that accurately predicts patient outcomes, a potential alternative to serial surveillance. This paper describes the overall workflow and processes performed in a 70-year-old man who was incidentally diagnosed to have a 5.4-cm juxtarenal aortic aneurysm in 2016 with successful fenestrated endovascular repair in 2023.
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