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Development and Evaluation of Decision Partner: A Decision Aid for HIV Remission Clinical Trial Participation
Rebecca R Moultrie1, Gail Henderson2, Sarah Nelson Potter3
1Center for Communication and Engagement Research, Center for Communication Science, RTI International, 3040 E. Cornwallis Road, P.O. Box 12194, 27709, Research Triangle Park, NC, USA. rmoultrie@rti.org.
Abstract:
HIV remission (or cure) clinical trials require potential participants to understand trial-related risks, approaches to minimize risks, potential benefits, procedures, and participation alternatives to make an informed decision. Decision aids (DAs) support preference-sensitive decisions. We report on the development and evaluation of a DA called Decision Partner, designed to support informed consent. We used an iterative, mixed-methods approach to develop and test Decision Partner. We conducted research and engagement activities among people living with HIV (PLWHIV), advocates, researchers, trialists, and clinicians which resulted in a product reflective of information required for informed choice. Among 20 PLWHIV, 90% rated that Decision Partner would be useful for decision-making. Decision conflict significantly decreased after using Decision Partner (37.3 to 16.8, p =.007) and knowledge significantly increased from pre to-post(z = -3.11, p <.01). Our findings indicated that Decision Partner holds promise to augment the informed consent process, in HIV remission trials.
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